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KMID : 1013220080060020142
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Jouranl of the Korean Society of Clinical Toxicology
2008 Volume.6 No. 2 p.142 ~ p.145
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Rhabdomyolysis after Lamotrigine Poisoning; A case report
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Kim Gun-Bae
Gu Hong-Du
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Abstract
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Lamotrigine is a newer anti-epileptic drug for adjunctive treatment of refractory epilepsy, partial seizures, generalized tonic-clonic seizures, and bipolar disorder. Lamotrigine overdose causes serious central nervous and cardiovascular problems, but reports are uncommon. Few lamotrigine overdoses have been described because anti-epileptic drug use is limited and usually used with combination of other anti-epileptic drugs. In addition, most patients visit emergency departments with multi-drug overdoses, so few cases of lamotrigine poisoning alone exist. We had a female patient visit our emergency department a couple of hours after a lamotrigine overdose treated with intravenous hydration and urine alkalization by NaHCO3. She recovered successfully without any evidence of renal injury. However, she developed profound rhabdomyolysis, a previously unreported complication of this medication. We suggest that serial creatine kinase levels should be measured after lamotrigine poisoning.
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KEYWORD
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Lamotrigine, Rhabdomyolysis, Poisoning
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